Gene function prediction from congruent synthetic lethal interactions in yeast
نویسندگان
چکیده
منابع مشابه
Gene function prediction from congruent synthetic lethal interactions in yeast
We predicted gene function using synthetic lethal genetic interactions between null alleles in Saccharomyces cerevisiae. Phenotypic and protein interaction data indicate that synthetic lethal gene pairs function in parallel or compensating pathways. Congruent gene pairs, defined as sharing synthetic lethal partners, are in single pathway branches. We predicted benomyl sensitivity and nuclear mi...
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BACKGROUND Synthetic lethal genetic interaction analysis has been successfully applied to predicting the functions of genes and their pathway identities. In the context of synthetic lethal interaction data alone, the global similarity of synthetic lethal interaction patterns between two genes is used to predict gene function. With physical interaction data, such as protein-protein interactions,...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2005
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100034